I commuted for about 9 months at the age of 44/45 when I started at Spirit and it wasn't the commute itself that made me feel old as much as it was the redeye flying that often came with commutable trips. A redeye leaves me reeling for a good day or two afterwards and trying to sleep in a crap-ass hotel between a 0600 trip finish and a 2000 show time was miserable to say the least.
That being said I currently live in base but am considering commuting again at the age of 46 because the base I live in (as well as the rest of our bases) sucks donkey balls.