The SIM eval interview process has included the B737, MD80, and B767. An airplane is an airplane, so don't worry about not having experience in type. It depends on availability, Interview pilots, and location for what type of SIM. Since you experience is mainly Part91 I would recommend brushing up on Part121 OpSpecs. Be yourself and don't lie about your background. The training always finds the true ability of the airman in the end. I think you would be better off at a regional airline if your goal is a major airline.