I would say that QOL wise if you can get into the top 10-20% of the seniority list at a regional then things are ok. But how long does that take at most places? The top 20% at regionals are pretty much there permanently and there is very little turnover. So, to get into that 20% you would have to get in at a new airline. Not many new regionals starting up nowadays.

So the short answer is to look outside the regionals for quality of life. My opinion would change if they offered new hires 17 days off per month, 4 weeks vacation per year, etc right from day one. Which, btw, if they really wanted to attract pilots this would do more than 10K bonuses and stuff like that.