I think the fact that you can call a 121 airline and be hired over the phone and put in class within a week or two answers the OP's question.
Don't you want to have some pride in the company you work for? There is absolutely no other reason to go to Mesa except for a Houston base. I've been in the regional recruiting world and I have seen many pilots with 5 or 6 plus checkride failures get hired at Mesa. As one post mentioned, DWI's? Go to Mesa. Failed out of 121 programs? Go to Mesa. And no, not all regionals have this practice. It's a dangerous practice. Just because you can force someone through training with 10 extra SIM sessions and 80 plus hours of IOE, doesn't make them a safe or professional pilot. It's a disgrace to our profession and hurts the entire industry. Have some respect for yourself and the industry. Go somewhere else.