For what it's worth, I have an easy, one-leg commute that I can do on company aircraft, coming in the same day as a PM trip. Honestly, I've felt zero stress from it. Sometimes I have to ride in the cockpit, sometimes in the FA jumpseat, but normally I get a good seat with no stress.
The extra time away from home, though, is just unsustainable, not to mention the hotel expense and the lost opportunity for picking up easy trips. For those reasons, I'm moving to base within my first year. Our trips just aren't generally commuter-friendly, and I knew that I'd eventually be moving to a domicile when I accepted the job. It's doable, but far from ideal with our schedules.