I just noticed on the (flimsy) artists rendering on Airbus' release that the 321NEO is in the new space-flex layout. Doors 2L/R are removed; 2 overwing exits are used and a smaller door 3L/R inserted - so technically you can have a layout that goes from 1L/R uninterrupted to 4L/R.

Can't you just see marketing do that? I know the planned layout is 197 but you'd have to assume there's a lav or 2 at 3L/R and maybe for our FA friends somewhere to put away the trash (see the 32K) in the space-flex galleys.