I read about a guy recently hired by a regional after being out 20 years. He did nothing beforehand, and made it through training no problem. Their training programs are set up now for pilots without much experience, which helps those out of the cockpit for a while.
Personally, I would do some stuff to get ready, like flying a local flight school sim with an instructor, IPC, etc.
Sounds like reasonable rumours going around about TSA Holdings (TSA/GoJet/Compass) merging into Republic. You can read about it on this website on various threads about the above four carriers...
Namaste...