A sim is a sim, standard sim profile for a lot of airlines is- takeoff, climb to 5000' (maybe a vector on the dep.), steep turns (30 and/or 45 degrees), track a VOR radial, hold somewhere, usually freeze the sim, slew you to the IAF, brief the ILS (practice good CRM here) and either land or execute the missed app. Get into the B-1 sim down there if you can and try to fly that profile a few times. Read the AIM and some FAR part 121 regs. (duty days/O2 requirements, alt. required, stuff like that). If you could find your way to Laughlin or Randolph and get an hour in a T-1 sim, that might help too.

I'm a Guard guy so I did the airlines full time prior to 9/11. I went civ. then mil. then civ./mil, then mil. only since 9/11...I'm on AD with the Guard but can leave whenever I want, pretty good deal...