I personally think cargo ops are more “at risk” for RPA operations than passenger ops.

That said, consider this:

Major freight airports are generally located in and around large metro areas. How so you think Joe Citizen and Mayor Bagodonuts would feel about streams of unmanned widebodies going over homes in the middle of the night?

Besides public acceptance at large, there are certification concerns about redundancy of aircraft and datalink robustness/security...especially operating on any significant scale.

Capital costs mean the value proposition simply does not exist for civil aviation, even discounting vaporware technology to enable it.

The Air Force will have remote piloted C-17s full of material and personnel going into hostile AOs *well* before the robots start to take our jerbs...