For the interview, study up on your atp stuff, and do well on the written. Don't get 100% though...that's an automatic disqualifier.
When I interviewed about 5 months ago, they had stopped doing sim evaluations and switched to a "situational interview." Basically, they sat me in the left seat (of a desk), gave me a scenario, and made me act as a captain on a flight. There are some good gouges on aviationinterviews.com
As for the QOL and ups and downs with the company...I haven't been around very long, but what I can tell you is this. The pilots I've worked with are all pretty much in agreement that the people are great and the management is terrible. Extentions, junior manning, etc. are the way of life. The pay is aweful, but seniority accrues quickly because people are always leaving.
I've been on reserve at DTW for about two months, and haven't "sat resevre" except for 1 day. I usually have a trip 2-3 days before my 'reserve' time arrives.
I've enjoyed my time here so far, but I'm 100% behind the union and getting us a new contract. I laughed out loud at the letter the management sent out proposing new FO pay rates. They need to fix things for EVERYONE.
That's my rant...