I can only speak for the some of the 75 domestic trips. Day flying is all but gone, but some of those routes we still have are trans con flights from CAE to I think OAK or SJC. Most 75 flight out of SDF are at night early morning. Some go through SDF others go to RFD, PHL, DFW and a few others. You may start at 7:00 p.m. in LAX, fly to SDF, sit for 3-4 hours, then fly to JAN with an arrival time around 5:00-6:00 a.m. Leave JAN around 10:00 p.m. go to SDF, sit for 3-4 hours then go back to LAX. Do it for a week, then go home.
Every fleet has different trips and layovers. International guys do much different trips as do ONT pilots and MIA pilots.
As far as what to do during the sort. You can sleep in snore city, eat some food, walk around, sit in the ready room and stare at the wall, or get on your computer. All types of fun to be had at 2 in the morning.