I prefer to live where I enjoy it the most and commute to work. Been doing it for the better part of 4 years at a regional. It isn’t as bad as some make it out to be, but it also isn’t always a cake walk. Having an understanding spouse goes a long way.
If you can live somewhere that has 6-8 flights /day to a hub you can be based it commuting isn’t bad. Having early flights to the hub and late flights from that hub to where you live is a huge plus. Working for a regional with a good commuter policy like the one that Endeavor has or like one of the American WO regionals (Envoy, PSA, Piedmont) helps tremendously.
I’m a CA at PSA and like I said I’ve been commuting for my time here. If you have any questions or want any insight let me know!