If you are reserve it will be hell. One year I spent 20 days in a row in an airport. Come home on day off, sleep, laundry, go back to work the next day on my day off. Rinse and repeat. As a line holder things can get a bit better to a lot better. If you can commute on the same days you work but make them really long is a hell of a lot better than having to go in the day before and back on your day off.
Until you stop doing it you just don't realize how much commuting sucks. With that said it depends on from where to where. Under an hour flight it's not that bad. Commuting coast to coast wedged in the jumpseat and ending up being awake for 18 hours isn't all that fun. Your kids, your wife, your dog all want to see you and you just want to curl up and sleep for 24 hours. Having sometime steal your jumpseat and you get to wait 3 hours for the next one or 2 leg it home not fun. Yes, people can steal the jumpseat by lying about which partner they work for and a few other methods that gate agents have no time to deal with.
I commuted 10 years to 4 different bases and the majority was pain in the arse. Yes, there were moments where life was good and easy but it was not the majority of the time.
If you can tolerate it great. If you go in with a clear view of what commuting life is going to be and your wife is on board fine. I live out west, want to stay out west, and simply won't apply to airlines that would cause me to commute to the east coast. Assuming they would love to have me (ha ha) it just isn't worth it to me. Everything in life is about trade-offs. Good luck..