I agree with the earlier poster about corp. shuttles. Some companies are already doing this. The Limited (Columbus, OH) I think has two CRJ-200's that run all over the east cost (CMH-TEB-CMH for sure). Take out the overhead bins.... and it'd be a nice corp. a/c...somewhere in the middle of the Challenger and Global.
These things won't ever haul freight.... I would guess it's cheaper to send 5 Caravans on a route than it would be 1 CRJ-100/200. This is probably the same conversation they were having about the B-1900/Dash-8 when the CL-65 came onto the market.