When I interviewed at Mesaba, the mention of commuting didn't seem to bother them at all. I would imagine that most airlines would rather have non-commuters though. I think this is mainly because they may be afraid that you will accept a job at another airline down the road in order to end you're commute.

It probably depends on who is doing you're interview. Odds are it won't hurt you, but I wouldn't bring up commuting unless they ask you about it. Like I said, they probably don't care and can't afford to be that picky right now.