Humans may be diurnal, but we HAVE been doing shift work for generations.

Yes, shift work is physically hard and has medically-proven downsides to both overall health, weight, and lifespan...but there are ways and opportunities to mitigate those effects for a pilot that doctors, nurses, police officers, factory workers, etc. simply don’t have.

I’d bet cargo pilots as a group are far healthier than 8-5 workers as a group.

Me? Don’t like hub turns, perhaps because I don’t nap well/easily in a sleep room. I personally prefer turns/out-and-backs that slide my body 4-5 hours vs. flipping day and night.