Commuting is a lot easier for pilots (cockpit jumpseat access) but plenty of FA's do it.

Ideally you want a city pair with multiple direct flights on multiple airlines. Also you don't want to commute between cities that are both crew bases (pilot and/or FA) for any airline.

So it depends on where you live too.

All the bases you mentioned are prone to weather, ORD maybe less than the east coast cities. Weather causes delays and cancellations which can fill up subsequent flights for days.