Pretty much what the others have already said. There are commutes and then there are commutes!. I did the former by choice for a little over a decade in pursuit of an upgrade and better schedules vs. a 2 hr drive to a senior domicile. It sounds like you would be setting up for the latter, which would also be setting you up for a divorce. We've got nine domiciles and one squadron spread all over the country, with more on the way. Realistically if you want to come work here, you should plan on picking one to live in or at least have a short online commute to. If the family absolutely, positively cannot relocate, then your best bet is to go work for an airline that flies a lot of international out of ORD. FAR117 has allowed us the ability to bunch trips together more than we used to, but that would still be a dicey headwind for you to fight on a monthly basis...for the better part of your career.
Best of luck to you!