KingAirPIC was refering to going to Mesa, building 121 Turbo-prop/jet SIC time, and then applying at a higher quality regional. Such as SkyWest, Expressjet, etc.

I believe Mesa will hire you with a 'wet' multi-commercial certificate.

http://www.mesa-air.com/pilots.asp

It says 500tt and 100me required, but I fly in and out of Dulles Intl every day and talk to the Mesa crews, and have bumped into 'wet' commercial guys and gals.

Give it a shot...what's the worst thing that could happen? They might say no?

Also try:
Piedmont Airlines
PSA
TSA
They all take 'wet' commercial pilots.