You probably want ORD or IAH.
Look at passrider.com to see about flights from your local airport to those two bases. My guess is that IAH will be a shorter flight, but ORD will have more flights if it's a major airport such as PHX. Someplace smaller such as ELP or ABQ it may be a toss-up as for the number of flights.
Good luck. It will suck at first but gets better with time.