I recently left a corporate/charter job and took a $50,000 pay cut just to get back in with an airline. I hated the corporate job. You are always babying spoiled rich people. You are the ramper, flight attendent, gate agent, dispatcher, and everything else. Everytime something is wrong, even if it is the weather it is your fault. No schedule. There is no union protection--duty time, days off, etc. (I'm not big pro-union but it really makes a difference). There are no travel benefits. I didn't think I used them until I was without them.
I know guys who love that flying and can't understand why I would ever want to "drive a bus". I would think really hard about what you like before you leave a major. 90% of the guys I flew corporate with were dying to get your job.