Sounds like you are a conspiracy theorist as well as a naive fool. Don’t let them chemtrails get you.
Pharmacognosy - the science of drug products from plants and other natural sources is not rocket science.
Plants don’t create these substances - generally alkaloids - because they wish to help mankind. They generally evolve these substances as a protective mechanism to poison or otherwise discourage animals that would otherwise eat them in much the same way that fugu (pufferfish) evolved the ability to concentrate tetrodotoxin to poison anything eating it. In the case of Kratom, Mitragynine is only one of approximately 40 varying stereoisomers of alkaloids found in it, and these alkaloids are variable in concentration and proportion from plant to plant. No actual standardization is possible because nobody knows which (if any) of these alkaloids is the (most) active ingredient. And every batch is different. AND NOBODY CAN STANDARDIZE A MIXTURE OF 40 COMPOUNDS.
Now you can keep citing cases like the “lady you have known for decades,” which any biostatistician would tell you constitutes an essentially meaningless “n of one” experiment, but all you demonstrate by such claims is your own ignorance. And I don't really mind you wasting your money or imperiling your own health buying worthless (or in this case potentially harmful) supplements but you are promulgating this idiocy on a board for airline pilots where encouraging others to follow the idiocy (or doing it yourself while flying) places the public at risk. That’s my gripe.
So go ahead and use. But when you have your seizures or your liver rots or your kidneys give out, don’t come whining about it. You made your choice, and wow, you sure will show those evil FDA scientists.
Come to think of it, if you go international, don’t bother with that yellow fever immunization either, that’s just an evil plot of theirs too no doubt. And the case-mortality rate for yellow fever actually isn’t much more than 20%.