"Major airlines can still require several thousand cockpit hours of experience before taking the controls of Boeing and Airbus jets, and haven't had a shortage of applicants. But Mr. Darby thinks regional airlines will be forced to drop as low as FAA licensing minimums -- 250 hours to get a commercial license necessary to serve as a co-pilot -- and bigger airlines will ultimately feel the pinch."
I doubt the majors will feel it much. They offer better QOL, pay, schedules or something that has nearly every regional pilot waiting in line for an interview or job.