Regional is comparable to a white collar job. Tradeoffs between the two... more time off in airlines but typically less career compensation than white collar (after you account for training costs, dues paying, and lost time value of money).
White collar will usually be there for weekends, holidays, and two weeks off at Christmas.
But regionals are better than most blue collar, and all unskilled jobs.
Majors are better than all of the above, only a very few niche professions might be better than upper tier majors.