Do your reserach on Colgan before you go there. You have the experience to go to what are commonly considered the "better" regionals. Consider that you may be at your regional for longer than you expect. Do what is right for your family, but it'll be tough anywhere you go for the first year.

On a side note, I've noticed lately that there have been a lot of people here spreading the "good word" of Colgan. They stand in a precarious position of not having a union while being owned by an airline with a unionized workforce that is ready to strike.