Everything is relative...
I have found hub turning (show times at 9 pm-10 pm, fly to hub...sleep 2 hours....depart 3-5 am..) to be absolutely brutal on my clock. Other guys thrive on them.
Sleeping in until midnight-2 am, flying a morning trip out and coming back to the hub around 8-10 am isn't easy--but I can hang with it. The break up of the sleep cycle is harder on me than moving it over.
Flying days with early morning starts is my next favorite....
Flying out around 3 pm and getting back 10-midnight is best for me. Sleep in, go to work, get home 1 am and booze a bit. Then repeat. Sort of like my college life....
Plenty at UPS/FDX for everyone....once you can hold it. YMMV....
But yeah...I think the hub turning would wipe me out early. Fortunately I do very little of it...