Good article. We've seen it and it's been discussed over on the cargo board.
I'll give you my take. I flew people for several years. Granted, it was for a lowly regional but the schedules there were not unlike any domestic major anymore. Now I fly primarily international, which presents the new problem of time zone changes and circadian rhythm swaps. All I can say is that I've not been nearly as tired here as I was flying domestic. If you can manage your sleep (i.e. sleep when you're tired) then this life is pretty easy.
I do agree that night hub-turning is probably the worst flying out there though, yet some guys happily lap it up.
To each their own.