Originally Posted by
Cicada
I would think the larger issue to be overcome first would be that a major would want to see you flying recently. So one way would be to go to a regional. That would get you the ATP CTP and the recent flying experience. Four years away from it needs to be dealt with to give you a shot.
This^^^^^Majors want to see plenty of recency of experience flying jets. You'll probably have to play the regional game...at least for a bit.