About a one in a million chance of going directly to a major after that long of a break in flying. And yes, I understand you've been doing some GA flying.
https://www.youtube.com/watch?v=KX5jNnDMfxA
Get some time at a regional and you'll be hired. It would probably be a bit of a reach, but you can also apply to Allegiant, Spirit, Frontier, JetBlue.