Ithaca is by far the best overnight. College town, lots to do because you're in town. But as someone else mentioned, the street noise can be bothersome if you're on a lower floor. I sleep with the hotel air con on constant fan or something to drown out noise. The bed in ITH is the most comfortable. ELM (Elmira NY) is good too for a lot of the same reasons, but I don't know if we're RON there now.
You try to find something you like on every overnight. A restaurant, a bar, some place to exercise that isn't dank hotel gym. I'm not one to pack food, never have been, so finding decent local places is fun for me. I'm not a slam clicker mostly, but I'm finishing a degree, so most of my overnights are packed with class work.