The vast majority of pilots are going to tell you that the domiciled gigs are better than the home-based ones, even if you commute.
Yes, living in base is king, but it's also a great privilege to live where you want and have the ability to commute to work.

Home-based gigs basically fall into either ACMI operators (Atlas, Southern, Kalitta, Omni, ATI etc) or Part 135 charters (XOJet, Nicholas, FlexJet, NetJets, etc.) And really, the fractionals aren't necessarily home-based as much as they list about 100 bases for you to live near, and PIT is always one of them.

So that said, the majority of current major airline 121 jobs are going to be better than the aforementioned home-based gigs for most people. In most cases, far superior. This is in terms of compensation, job security, retirement, schedule flexibility etc. In general, in order to recoup the loss of home-basing a pilot, you will be scheduled to be gone longer in order to not have to pay to position you as much. ACMI operators will routinely send you on 10-17 day trips, while the fractional life will have you on a 8/6 schedule (or 7/7 if you're lucky) on an endless loop.

Not worrying about a ride to work is great. I've done it. But even better is getting paid a lot more, having twice the retirement, and knowing my company isn't likely going anywhere.