I have been commuting from OMA to SFO for four years now. United introduced a non-stop right after I bid it, and that has made all the difference in the world for me. The two-leg commutes through DEN (and once on Alaska through SEA, and once on SWA through PHX) are quite miserable.
The problem with DEN-SFO is the ATC delays for SFO begin around 6a SFO time. My non-stop OMA flight was always airborne before the delays were enacted, but.....if I go through DEN, I found that the 8a, 9a, 10a flights would all be impacted by delays in SFO. Senior bubbas listed on the 10a, 11a flights would start showing up for the delayed 8a. Accordingly, I would go from #1 on the list, down to...well, not getting on the flight. So....I will not go through DEN on my way to work, and just accept going in a day early if need be to protect my trip.
I have family in the Bay Area and a car out there, so going in a day early....or getting stuck for the night....is not a disaster for me. I DO bid max number of work blocks = 2 and that helps with the QOL. The going back and forth part is the only part I don't like as it essentially takes >6 hours. Two commutes/month is manageable.
My advice? Don't do it. As others mentioned, coming off of a 12-15 hour flight and then two-legging it home....sucks. 777 is a sweet machine, and I enjoyed my time on it in SFO. But as long as you have FAR in your address, you will have some limits on what makes sense.