Where you'll likely first see remote piloted cargo aircraft is Alaska, and it'll be Caravan-sized aircraft. After some time of proving reliable there, those size aircraft will spread to domestic cargo feeder operations into rural areas of the Plains and Southwest.
We're a LONG way from commercial remote-piloted widebody (or narrowbody) transport aircraft in 121 cargo operations into LAX, ONT, MEM, SDF, IND, RFD, JFK, MIA, etc.