Where you work is a big factor in how commuting works. For example, on Endeavor your second flight is positive space if you miss the first (and it's a Delta flight), which takes stress away. On the mainline level, Delta has that but you ALSO can reserve the jumpseat and if you get bumped by a fed they positive space you. Other regionals might also have commuter policies, but you need to know what they are.

I used to do a 2 leg long distance commute and it meant that if I didn't have at least 3 days off I didn't even bother going home, I would just go for the biggest stretches of days off I could get. I have a much shorter commute now and it doesn't bother me at all.

Like everyone else says, the shorter number of legs the better but ALSO, how many commuters live where you do is a massive factor. If there are always 4 or 5 pilots trying to commute on a given flight there is a lot more stress than if there are 4 or 5 of you total and you rarely even see the others.