It would depend on flight availability and traffic. For me, three hours is the outer limit on driving, especially in typical metro traffic. But typically I'd drive for three hours (have done five but that's no fun, pretty much have to come in the night before for an early report.

The five hour drive was to avoid a 2-leg commute. Didn't last long, literally a few weeks and then took long-term military orders until I could hold a different base.