when I was flying a USPS run, would go to the Grove airport (from Joplin) for MX....flew over that lake many times.
Ask around... remember CFI trucking had a flight department and remember them looking for locals in Springfield and Joplin. Ask around....you might be surprised.
If you happen to live in an location where a freight pilot is NEEDED, or are willing to relocate, flying cargo can be pretty good, with lots of time at home. If you try to commute....there might be better options unless you are young and willing to mover every few months. Good luck!
Freight is definitely an option, but it might be more about finding the right route, since most companies try to find a local or a person who is willing to move due to QOL and fatigue issue....have done runs 5 hrs away from home, driving home for the weekend Saturday afternoon, leaving Monday am...it's doable, but honestly, it wears you out after a few months.