The mic on the uflymike does introduce a significant amout of hiss and background noise to the intercom. There is a mic bias adjustment on the side of the control box but if you adjust the bias to be low enough to reduce the background noise it reduces the mic gain so much that ATC can have trouble hearing your transmissions. In my opinion it's not really a great setup. Additionally all the components (mic boom, control box, cords and plugs) seem cheaply made and somewhat fragile.

If you already have a compatible Bose n/c headphone the uflymike add-on is an ok solution. If you don't already have a Bose headset I wouldn't recommend buying one and the uflymike system, I'd recommend getting a real aviation n/c headset. The uflymike system is not very robust, and inferior in almost all ways.

Just my opinion, based on using a QC35/uflymike setup on the 737 for 6 months. YMMV.