If you don't meet the min requirements for the airline that you want (or the one that will get you quick PIC time), then I guess you have 2 choices.

1. Continue doing what you are doing (cfi, 135, flying rubber dog-sh!t out of hong kong, whatever) as long as it's a secure job and pay is decent relatively speaking, until you meet the mins.

2. Take a regional job if you get an offer, even if it means being furloughed in the near future, or if it's with an outfit like AE with a 7 year upgrade. Do this with the knowledge that the worst case is you'll be jobless. If you can handle that idea, then go for it. The up side is that you'll be jobless with a few hundred hours of jet time in your book, even if it is SIC. Just watch for training agreements, etc, that make you pay back the cost of training if you leave before some prescribed period of time. You don't want to get the offer from your ideal company only to be tied down by $20k in debt to your current employer.