Bill, do I know you? I'd rather be shoveling for the elephants under the stands in JFK.

To anwser the question about the MD80 : If you left the regionals because of the trips well guess what? You're still there. Every even numbered leg for two years was in to ATL. After a four day trip it would take me a couple of days to recover. Once the TRWs start up in the afternoon all bets are off. This of course is my opinion.
The ER on the other hand: Every even numbered leg is into JFK. That doesn't sound very good but you do it once a trip. For me international is much easier on my body. Two maxims of international flying: anyone can rally for one landing and the worst layover in Europe is better than the best Domestic. A couple of caveats; as a new hire it is going to take you much longer to get comfortable, and those international layovers don't look so good when you add Africa and the UK.

The second post asked about Houston. With Continental available it may be possible. I do ORD- NYC with no problem. Check a bid package and Continental's schedule and you should be able to find your anwser. I've never been called right at 12 hours but since the majority of the sign-ins are in the late afternoon you should be ok.