If you leave aviation, you are likely leaving any chance of ever making it to an LCC/Major and most certainly a Legacy.
If it will take 5-ish years for the industry to leave, and you leave your slot at the regionals, you will have put yourself back 10 years at a minimum. And with corporate aviation not hurting for pilots, without recent time in a jet, you won't be a top candidate. Exploring a leave of absence isn't a bad idea, but that might not be available to you in the length of time you might desire (contract dependent).
Only you know if you will be fine leaving professional flying completely behind you, don't delude yourself into thinking coming back will be easy if that's where your head at. The landscape will not be the same as the pilot shortage has evaporated and won't see a comeback for a while.