If you can see yourself doing it. Go! Even if you return to flying later you could regret the road not traveled.
Now on the seniority side of things. If you build time while there’s a drought in turbine and can get pic time eventually you’d be way better off. But the career is feast or famine. If that reality makes you want to go for the tangible now then go and remember you could always come back. But you will be returning to a regional as a FO at the bottom of the list.