Bose QC-25 or 35 with the UFlyMike setup is the perfect compromise. Light weight, works great with over the ear ANR, comfortable, and not as big as the Bose aviation headsets. Bonus, you can use the QC headphones when flying in the back and not look like a tool.
They are not TSOd (yet), so if that is an issue, maybe have the telex headset as backup in case someone cares. I have yet to run into anyone who does.