Yeah that's pushing it.

I've done several drive commutes (as well as 2-6 hour air commutes).

Traffic is a big factor, increases fatigue and irritation. Frankly I won't do traffic for more than a hour, if it's rush hour I'll go to work early or wait it out before I go home (gym, movie, nap, etc).

Also have to consider the types of trips you're doing... getting up at 0200 for a 0500 show to do a transcon is one thing. Getting up at 0100 for a 0400 show to do a 4-5 leg regional day is something else entirely.

Also applies to the drive home, late finishes can be dangerous if you're tired. I'll have a cup of joe at TOD to get me through the arrival and subsequent drive home. During the day I make phone calls and catch up with friends and family. That''s not an option late, so I have a spectrum of driving music... the later the drive home, the more energetic the music culminating with heavy metal and ultimately German heavy metal. If you start doing the head bob thing, pull the eff over and sleep... lost a friend to that years ago.

Up to two hours is easy, I can make that without a bathroom stop. Three hours might be OK, but that's starting to be a lot both for fatigue at work and safety on the drive home.

I've done a five hour drive to reserve, somewhat mitigated by overlapping reserve start time with the tail end of the drive. But that sucked, wouldn't do it again. It was highway but pretty busy highway with half the drive in large metro areas. Air option on that one was two leg through a weather-probe hub, and the second (express) leg got CANX a lot.

If you have little to no traffic, you might be fine with 3-4 hours on cruise control, if you have some say in your starting and ending times. Problem with early starts is if something happens at work, it might be hard to explain to the FAA that you were fit to fly. At least with an air commute you can claim to have slept on the plane. Late finishes are dangerous to your life if you push it the drive home.