Assuming the airlines do the right thing and reduce/eliminate the terribly fuel and airspace inefficient RJs in the next 5 years:

If you've got talent, treat the regionals like graduate school. Get in where you can upgrade quickly and graduate (Multi engine turbine pic) and then get out.

RJ QOL, work rules and crew meals don't mean squat switch to your future major airline's hiring board.

Respectfully.