It could be done. There are currently four QX flights per day from Reno to Seattle, and two per day from Reno to Portland. These tend to be pretty full and there are frequently pilots from other airlines who want to sit in the jumpseat. Horizon DOES have a commuter policy. If you follow the rules and still can't make your commute, then you won't get penalized.
Commuting from Reno could work, but I personally wouldn't recommend it as a new hire. It's stressful and will probably require you to commute on at least some of your days off.