Depends on the job.
Sometimes insurance requirements dictate hiring.
For a CFI position that requires a certain amount of dual given or a CFII or time in a specific airplane sure go ahead and reply but at least mention that you are aware of the fact you don’t meet the requested.
” I am aware would you kindly consider my application” kinda thing.
Are they asking for 2500 TT and 500 Turbine and you’ve got 1700hrs and only piston time then no. Then again, if the ad has been up for a while or keeps popping up then give it a shot.
As you stated it’s not an outright yes/no.