Been using the standard Stealth 22" bag from Luggage Works for over 15 years now on RJs, 757/767 and the 320. My first one lasted nearly 10 years with just a wheel replacement and minor frame repair. I really only replaced it when I left the regionals to use up a uniform allowance I'd accumulated. Second one just had to have the wheels replaced at about the 6.5 year mark. I've never used it but I've known a lot of people swear by the refurbishment service from Luggage Works.

It's really been great for everything from RJ flying to 6-day international trips. If you commute (especially on rjs) it's almost a must. It's basically indestructible. The weight is the main drawback of this bag but also what leads to its durability. They have a new version with a carbon fiber frame that is intriguing. Something like 30% lighter with as much or more strength. It's a bit more expensive than the standard but I think when it comes time to replace my current bag, I'll be looking hard at the carbon fiber.

If you search the forum for "Luggage Works" you'll probably find a lot of previous topics on this.