My advice. If you were 62+ I would recommend staying put. At age 40, I would say go, NOW.
Whether you commute or move, is up to you. But there are so many advantages, I think you should. Three years as a FO you will be making $160K. By then or shortly after, you will be moving into the CA seat. You will be making $250K at the minimum, and even more if you pick up premium or eventually fly wide body.
Whether your wife’s situation has one of you commute or moves with you and finds another position (her experience sounds extremely marketable), you are going to do so much better.
As others said, in the next couple of years, most of the regionals will crater or merge. I would not want to be banking on that position you have. The company many not be there.