I think it really would be a matter of economics. I believe all the EWR or IAD to India are possible without Russian airspace. It just takes longer and costs more. Worst case is a tech stop for fuel. If the ticket prices are high enough and the demand is there, I think they would do it.
Same with Asia and Australia. All are possible from the west coast. Someone in EWR will just have to connect through SFO or LAX.