It's kinda funny that for most, their ultimate goal is to get on at: Delta, United, AA, SWA, Alaska, UPS, and FDX....none of which are home-based. Of course they are willing to make the bulk of their career changing bases, aircraft, commuting, or living in a hub city. You have to step down (skipping regionals) ACMI and Charter airlines before you get to the home based argument. The places where some remain commuting till the end and some cherish tickets, some attempt to have more retirement/scheduling since none of them can compare to biggies.
Since this is the ABX Latest thread, I will add to it their most recent announcement of additional (4) aircraft in the DHL system. Surely these acquisitions are from Kalitta moving out of the 767 DHL domestic ops, thereby bringing ABX to a 6 aircraft expansion during the 2022 year. Movement is a good thing (even for a domiciled airline!).